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Key clinical trials in gynaecological oncology.

Morrison J, Kehoe S

Nuffield Department of Obstetrics and Gynaecology, John Radcliffe Hospital, Headington, Oxford OX3 9DU, UK. jo.morrison@os-gyn.ox.ac.uk <jo.morrison@os-gyn.ox.ac.uk>

AIMS: To review the most important clinical trials which have impacted the management of gynaecological cancers, in conjunction with some ongoing studies of interest. METHODS: PubMed and Cochrane databases were searched to find clinical trials and meta-analyses in vulva, cervical, endometrial and ovarian cancers. Other pertinent literature was also used. RESULTS: The majority of trials related to ovarian and cervical cancers, and the least associated with vulval cancer. CONCLUSIONS: To ensure evidence based medicine, trials in gynaecological cancers must be supported. Notably, surgical trials are on the increase in the last decade, but are still a minority when compared with non-surgical interventions.

Published 9 October 2006 in Eur J Surg Oncol, 32(8): 887-91.
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