Oncology Research Today is a free monthly online journal that collates and summarizes the latest research about Oncology, including details on cancer, surgery, chemotherapy, radiotherapy.

Principles of the therapeutic use of monoclonal antibodies in oncology.

Fridman WH

INSERM U255, IFR des Cordeliers, Universités Paris-5 & Paris-6 et Hôpital Européen Georges-Pompidou, AP-HP, Paris, 15, rue de l'Ecole-de-Médecine, 75006 Paris, France. herve.fridman@u255.bhdc.jussieu.fr

Monoclonal antibodies have reached the stage of therapeutic agents, mostly in oncology, as illustrated by their wide use in lymphoma, breast cancer or colorectal cancer. The unravelling of their mechanisms of action and their interactions with their cellular receptors allows us to engineer new classes of therapeutic antibodies with increased efficacy. The identification of some of the tumour escape mechanisms may also help to define new approaches for patient selection and immunomonitoring. The present review addresses these various aspects.

Published 28 April 2006 in C R Biol, 329(4): 255-9.
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