Oncology Research Today is a free monthly online journal that collates and summarizes the latest research about Oncology, including details on cancer, surgery, chemotherapy, radiotherapy.

Three-year single institution audit on transfusion requirements in oncology patients.

Dernedde U, Dernedde R, Shepstone L, Barrett A

Norfolk and Norwich University Hospital NHS Trust, Norwich NR4 7UZ, UK. ulrike.dernedde@doctors.org.uk

AIMS: To assess recent developments in the use of transfusions. MATERIALS AND METHODS: Data from hospital-based sources were condensed in a single spread sheet covering 1611 transfusions of a total of 881 patients together with data on 25,264 treatment sessions in 6137 patients within a time period between 1 August 2001 and 31 July 2004. RESULTS: Our audit showed an increase in transfusions of 25% in 3 years. This was accompanied by an increased threshold for transfusions, as shown by a significant rise in mean haemoglobin trigger levels from 8.53 to 8.86 g/dl (P<0.001) as well as an increase in treatment sessions and patient numbers - especially for chemotherapy or combinations of chemotherapy and radiotherapy. The highest transfusion rates and also the greatest increments occurred in patients with carcinoma of the ovary, lung and pancreas. Within these groups, treatment regimens as well as treatment lines were additional predictive factors. CONCLUSIONS: This audit gives a detailed view on rising trends in transfusion requirements and, in light of anticipated restrictions on resources, it identifies high-risk areas, where the use of alternatives, such as erythropoietin, could be considered.

Published 16 April 2007 in Clin Oncol (R Coll Radiol), 19(4): 223-7.
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